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spoVE [2019-07-01 09:58:10]
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spoVE [2019-07-01 09:58:10]

SEDS family peptidoglycan glycosyltransferase, required for spore cortex peptidoglycan synthesis
locus
BSU15210
pI
9.85
mw
39.97 kDa
protein length
366 aa Sequence Blast
gene length
1101 bp Sequence Blast
function
spore cortex peptidoglycan synthesis
product
SEDS family peptidoglycan glycosyltransferase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    1,590,317 1,591,417

    The protein

    Protein family

  • [protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|FtsW]/[protein|B405B3C21B464F904BBB2AFD5DA21ADE45B4DD96|RodA]/[protein|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|SpoVE] family (according to Swiss-Prot)
  • [SW|SEDS proteins] (shape, elongation, division, and sporulation) [Pubmed|27525505]

    • Paralogous protein(s)

  • [protein|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|FtsW], [protein|B405B3C21B464F904BBB2AFD5DA21ADE45B4DD96|RodA]

    • Structure

  • [PDB|6BAR] (from Thermus thermophilus,corresponds to aa 99... 357, 38% identity) [pubmed|29590088]

    • [SW|Localization]

  • integral membrane protein, forespore [Pubmed|17981970]

    • Expression and Regulation

    Operons

    genes
    [gene|D48B7591467C493D2214D37AEA83643FE8C27BC6|murE]-[gene|4D3D4429E1F387BACB0D5A1084AA8DF179A16685|mraY]-[gene|0A9FF5A66F73464A780914A1424979CE753B3D9C|murD]-[gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]-[gene|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]-[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]-[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
    description
    [Pubmed|1391053]

    sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|8320223], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]

    • regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]
  • [protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID]: repression, [Pubmed|15383836], in [regulon|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID regulon]

    • regulation

  • expressed during vegatative growth [Pubmed|1391053]
    • view in new tab

    genes
    [gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]
    description
    [Pubmed|1391053]

    regulation

  • expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]) [Pubmed|1391053]
    • view in new tab

    genes
    [gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]-[gene|D52FDB5015B10E9B26D7FED5708457890C6EA43D|murG]-[gene|5E11616A51EE2CD1B8D3E33B18483521C504AD1F|murB]-[gene|B66FC02948DABBCE64DE2629D6E33E05647B4EEF|divIB]-[gene|5CDB49209BDCA86E09D6287DFC16B278D9A71379|ylxW]-[gene|081EA0CBCDA7ECDE8D128DD091C132BB194D19EB|ylxX]-[gene|1C6CADD1808CA84CBC19D623DACF4D398EB43174|sbp]
    description
    [Pubmed|1391053]

    regulation

  • expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell ([protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]) [Pubmed|1391053]
    • view in new tab

    additional information

  • the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]

    • Biological materials

    Mutant

  • BKE15210 ([gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE15210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGCAATCGACACCCCAA, downstream forward: _UP4_TAACGAATGTATTTCCAAGC
  • BKK15210 ([gene|5DE602D97D903D9AE38ED05D5A5F1B3A2DC1D58E|spoVE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK15210 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAGCAATCGACACCCCAA, downstream forward: _UP4_TAACGAATGTATTTCCAAGC

    • References

  • 20417640,17981970,8320223,1391053,15383836,26883633,27525505,29590088